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awesome-bio-agent-skills

A curated collection of AI agent skills for biomedical research, covering genomics, proteomics, single-cell analysis, clinical AI, and protein design.

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Awesome Bio Agent Skills

A curated collection of AI agent skills for biomedical research, covering genomics, proteomics, single-cell analysis, clinical AI, and protein design.

Now tracking NVIDIA BioNeMo Agent Toolkit, Claude Science built-in skills, and the emerging ecosystem of agent-callable tools for life sciences.

1,722 deduplicated skills from 22 open-source repositories, organized into 16 categories. Each skill is a self-contained SKILL.md folder compatible with Claude-based agent frameworks (OpenClaw, NanoClaw, Biomni).


About BioTender

This project is created and maintained by BioTender.

BioTender is a Chinese AI-for-Biology intelligence and media platform covering protein design, structure prediction, virtual cells, AI drug discovery, biological foundation models, scientific agents, AI4Bio startups, and frontier research.


Contents


Genomics

526 skills — WGS/WES analysis, variant annotation, GWAS, CNV, structural variants, haplotype phasing, genome assembly.

View all 526 skills
Skill Source Description
bio-alignment-amplicon-clipping bioskills Trim PCR primers from aligned reads in amplicon-panel BAMs using samtools ampliconclip. Use when processing SARS-CoV-2 ARTIC, hereditary cancer pan...
bio-alignment-filtering bioskills Filter alignments by flags, mapping quality, and regions using samtools view and pysam. Use when extracting specific reads, removing low-quality al...
bio-alignment-indexing bioskills Create and use BAI/CSI indices for BAM/CRAM files using samtools and pysam. Use when enabling random access to alignment files or fetching specific...
bio-alignment-io bioskills Read, write, and convert multiple sequence alignment files using Biopython Bio.AlignIO. Supports Clustal, PHYLIP, Stockholm, FASTA, Nexus, and othe...
bio-alignment-msa-parsing bioskills Parse and analyze multiple sequence alignments using Biopython. Extract sequences, identify conserved regions, analyze gaps, work with annotations,...
bio-alignment-msa-statistics bioskills Calculate alignment statistics including sequence identity, conservation scores, substitution matrices, and similarity metrics. Use when comparing...
bio-alignment-multiple bioskills Perform multiple sequence alignment using MAFFT, MUSCLE5, ClustalOmega, or T-Coffee. Guides tool and algorithm selection based on dataset size, seq...
bio-alignment-pairwise bioskills Perform pairwise sequence alignment using Biopython Bio.Align.PairwiseAligner. Use when comparing two sequences, finding optimal alignments, scorin...
bio-alignment-sorting bioskills Sort alignment files by coordinate or read name using samtools and pysam. Use when preparing BAM files for indexing, variant calling, or paired-end...
bio-alignment-structural bioskills Align protein structures using Foldseek 3Di, TM-align, US-align, DALI, or Foldmason for structural MSA. Predict, score, and superpose backbone coor...
bio-alignment-trimming bioskills Trim multiple sequence alignments using ClipKIT, trimAl, BMGE, Divvier, or HMMcleaner with mode selection guidance per downstream goal. Use when re...
bio-alignment-validation bioskills Validate alignment quality with insert size distribution, proper pairing rates, GC bias, strand balance, and other post-alignment metrics. Use when...
bio-atac-seq-allele-specific-accessibility bioskills Detect allele-specific chromatin accessibility from ATAC-seq using WASP, GATK ASEReadCounter, or RASQUAL. Use when mapping cis-regulatory genetic v...
bio-atac-seq-atac-peak-calling bioskills Call accessible chromatin regions from ATAC-seq BAM files using MACS3, MACS2, Genrich, or HMMRATAC. Use when identifying open chromatin from aligne...
bio-atac-seq-consensus-peakset bioskills Build a differential-ready consensus peakset from per-replicate ATAC-seq peaks using iterative overlap removal, fixed-width re-centering, and major...
bio-bam-statistics bioskills Generate alignment statistics using samtools flagstat, stats, depth, coverage, and mosdepth. Use when assessing alignment quality, calculating cove...
bio-basecalling bioskills Convert raw Nanopore signal data (FAST5/POD5) to nucleotide sequences using Dorado basecaller. Covers model selection, GPU acceleration, modified b...
bio-bedgraph-handling bioskills Create, manipulate, and convert bedGraph files for genome browser visualization. Covers bedGraph format, conversion to/from bigWig, normalization,...
bio-biomart-queries bioskills Bulk-query Ensembl BioMart (and other BioMart instances) for cross-database ID mapping, gene/transcript/exon coordinates, and ortholog tables. Use...
bio-causal-genomics-colocalization-analysis bioskills Test whether two or more traits share a causal variant at a locus using Bayesian colocalization (coloc.abf, coloc.susie, HyPrColoc, moloc, eCAVIAR,...
bio-causal-genomics-effector-gene-prioritization bioskills Maps GWAS-implicated loci to candidate effector (causal) genes by integrating variant-to-gene (V2G) features via Open Targets L2G (Mountjoy 2021),...
bio-causal-genomics-fine-mapping bioskills Resolves GWAS associations to candidate causal variants and credible sets via SuSiE, susie_rss, FINEMAP, CAVIAR, DAP-G, PAINTOR, PolyFun, SuSiEx, M...
bio-causal-genomics-genetic-correlation bioskills Estimate bivariate genetic correlation (rg) between traits from GWAS summary statistics or individual-level genotypes using cross-trait LDSC, HDL,...
bio-causal-genomics-genomic-sem bioskills Fits structural equation models to GWAS summary statistics using GenomicSEM (Grotzinger 2019), including common-factor models, confirmatory factor...
bio-causal-genomics-mediation-analysis bioskills Decompose total effects into direct and indirect paths through mediators using mediation, CMAverse 4-way, HIMA/HIMA2 high-dimensional, BAMA, two-st...
bio-causal-genomics-mendelian-randomization bioskills Estimate causal effects of an exposure on an outcome from GWAS summary statistics using genetic instruments. Implements IVW (fixed/random), MR-Egge...
bio-causal-genomics-pleiotropy-detection bioskills Detect and adjust for horizontal pleiotropy in two-sample Mendelian randomization by distinguishing uncorrelated (UHP) from correlated (CHP) pleiot...
bio-causal-genomics-proteome-mr-drug-target bioskills Runs cis-pQTL Mendelian randomization for drug-target validation using UKB-PPP (Olink), deCODE (SomaScan), Fenland, INTERVAL, ARIC, and FinnGen-PPP...
bio-causal-genomics-transcriptome-wide-association bioskills Performs gene-level association from GWAS summary statistics via genetically predicted tissue expression using FUSION, PrediXcan, S-PrediXcan, S-Mu...
bio-cfdna-preprocessing bioskills Preprocesses cell-free DNA sequencing data including adapter trimming, alignment optimized for short fragments, and UMI-aware duplicate removal usi...
bio-chipseq-allele-specific-binding bioskills Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter;...
bio-chipseq-chip-deep-learning bioskills Trains and applies base-resolution deep learning models on ChIP-seq / ChIP-nexus / CUT&RUN data. Uses BPNet (Avsec 2021 Nat Genet 53:354; soft moti...
bio-chipseq-peak-calling bioskills Calls ChIP-seq peaks with MACS3, MACS2, HOMER, or SPP across narrow (TF) and broad (histone) modes. Handles input control matching, fragment-size m...
bio-chipseq-visualization bioskills Visualizes ChIP-seq data using deepTools (computeMatrix, plotHeatmap, plotProfile, bamCoverage, bamCompare), pyGenomeTracks (modern INI-driven trac...
bio-clinical-biostatistics-adaptive-designs bioskills Designs adaptive clinical trials including group-sequential (O'Brien-Fleming, Pocock, Lan-DeMets spending), sample-size re-estimation (blinded Frie...
bio-clinical-biostatistics-categorical-tests bioskills Tests associations between categorical variables in clinical data using chi-square, Fisher's exact, Boschloo, Cochran-Mantel-Haenszel, and modern M...
bio-clinical-biostatistics-power-sample-size bioskills Computes sample size and power for clinical trials including continuous, binary, and time-to-event endpoints; superiority, non-inferiority, and equ...
bio-clinical-databases-acmg-classification bioskills Applies ACMG/AMP 2015 framework with ClinGen SVI specifications, Tavtigian 2018/2020 Bayesian point system, Abou Tayoun 2018 PVS1 decision tree, Pe...
bio-clinical-databases-clinvar-lookup bioskills Queries ClinVar for variant pathogenicity classifications, ClinGen VCEP curations, and somatic-vs-germline interpretations via REST API, weekly VCF...
bio-clinical-databases-dbsnp-queries bioskills Resolves rsIDs, navigates RsMergeArch/SNPHistory merge chains, and converts between rsID, SPDI, HGVS, and VCF representations using the dbSNP Build...

...and 486 additional genomics skills in the skills/bioskills/, skills/openclaw/, skills/sciagent/ directories.


Proteomics

167 skills — mass spectrometry analysis, structure prediction, protein design, binding affinity optimization.

View all 167 skills
Skill Source Description
bio-atac-seq-nucleosome-positioning bioskills Map nucleosome center positions, occupancy, and fuzziness from ATAC-seq fragment-size patterns using NucleoATAC, ATACseqQC, DANPOS3, or scprinter....
bio-data-visualization-sequence-logos bioskills Build sequence logos from aligned DNA, RNA, or protein motifs using ggseqlogo (R), Logomaker (Python), or WebLogo with explicit bits vs probability...
bio-generative-design bioskills Designs novel molecules using REINVENT 4 (de novo, scaffold decoration, linker design, R-group, molecular optimization), MolMIM, Diffusion-based ge...
bio-hi-c-analysis-hic-differential bioskills Compare Hi-C contact matrices between conditions to identify differential chromatin interactions. Compute log2 fold changes, statistical significan...
bio-hi-c-analysis-tad-detection bioskills Call topologically associating domains (TADs) from Hi-C data using insulation score, HiCExplorer, and other methods. Identify domain boundaries and...
bio-immunoinformatics-mhc-binding-prediction bioskills Predict peptide-MHC class I and II binding affinity using MHCflurry and NetMHCpan neural network models. Identify potential T-cell epitopes from pr...
bio-immunoinformatics-neoantigen-prediction bioskills Identify tumor neoantigens from somatic mutations using pVACtools for personalized cancer immunotherapy. Predict mutant peptides that bind patient...
bio-interaction-databases bioskills Query protein-protein and gene interaction databases (STRING, BioGRID, IntAct, SIGNOR, Reactome, HuRI, HuMAP, OmniPath, ConsensusPathDB, DIP). Use...
bio-ml-docking-rescoring bioskills Performs ML-based protein-ligand pose prediction and scoring using DiffDock-L (diffusion-based), Boltz-1 / Boltz-2 (foundation model with affinity)...
bio-molecular-io bioskills Reads, writes, and converts molecular file formats (SMILES, InChI, SDF V2000/V3000, MOL2, PDB, MMTF) using RDKit and Open Babel with rigorous handl...
bio-molecular-standardization bioskills Standardizes molecular structures using ChEMBL chembl_structure_pipeline and RDKit rdMolStandardize covering sanitization, salt/solvent stripping,...
bio-pdb-geometric-analysis bioskills Perform geometric calculations on protein structures using Biopython Bio.PDB. Use when measuring distances, angles, and dihedrals, superimposing st...
bio-pdb-structure-io bioskills Parse and write protein structure files using Biopython Bio.PDB. Use when reading PDB, mmCIF, and MMTF files, downloading structures from RCSB PDB,...
bio-pdb-structure-modification bioskills Modify protein structures using Biopython Bio.PDB. Use when transforming coordinates, removing atoms or residues, adding new entities, modifying B-...
bio-pdb-structure-navigation bioskills Navigate protein structure hierarchy using Biopython Bio.PDB SMCRA model. Use when accessing models, chains, residues, and atoms, iterating over st...
bio-phylo-tree-manipulation bioskills Modify phylogenetic tree structure using Biopython Bio.Phylo. Use when rooting trees with outgroups, midpoint, or MAD methods, pruning taxa, collap...
bio-population-genetics-population-structure bioskills Analyze population structure using PCA and admixture analysis with PLINK and ADMIXTURE. Identify population clusters, assess ancestry proportions,...
bio-pose-validation bioskills Validates docked / generated protein-ligand poses using PoseBusters physical-validity tests, strain energy quantification, geometric checks (planar...
bio-primer-design-primer-validation bioskills Validate PCR primers for specificity, dimers, hairpins, and secondary structures using primer3-py thermodynamic calculations. Check self-complement...
bio-protac-degraders bioskills Designs PROTACs, molecular glues, and bivalent degraders with explicit handling of E3 ligase choice (VHL, CRBN, IAP, MDM2, KEAP1), linker design (l...
bio-proteomics-data-import bioskills Load and parse mass spectrometry data formats including mzML, mzXML, and quantification tool outputs like MaxQuant proteinGroups.txt. Use when star...
bio-proteomics-dia-analysis bioskills Data-independent acquisition (DIA) proteomics analysis with DIA-NN and other tools. Use when analyzing DIA mass spectrometry data with library-free...
bio-proteomics-peptide-identification bioskills Peptide-spectrum matching and protein identification from MS/MS data. Use when identifying peptides from tandem mass spectra. Covers database searc...
bio-proteomics-protein-inference bioskills Protein grouping and inference from peptide identifications. Use when resolving protein ambiguity from shared peptides. Handles protein groups and...
bio-proteomics-quantification bioskills Protein quantification from mass spectrometry data including label-free (LFQ, intensity-based), isobaric labeling (TMT, iTRAQ), and metabolic label...
bio-proteomics-spectral-libraries bioskills Build, manage, and search spectral libraries for proteomics. Use when creating or working with spectral libraries for DIA analysis. Covers DDA-base...
bio-qsar-modeling bioskills Builds QSAR / QSPR models using chemprop D-MPNN, MolFormer, Uni-Mol, ChemBERTa, random forest baselines, and Gaussian processes with explicit handl...
bio-rna-structure-ncrna-search bioskills Searches for non-coding RNA homologs and classifies RNA families using Infernal covariance model searches against the Rfam database. Identifies str...
bio-rna-structure-structure-probing bioskills Analyzes experimental RNA structure probing data from SHAPE-MaP and DMS-MaPseq experiments using ShapeMapper2. Converts mutation rates to per-nucle...
bio-scaffold-analysis bioskills Analyzes chemical libraries by scaffold using Bemis-Murcko scaffolds, generic frameworks, cyclic skeletons, matched molecular pair (MMP) analysis v...
bio-similarity-searching bioskills Performs molecular similarity searching using Tanimoto, Tversky, Dice, and cosine coefficients on bit/count fingerprints with explicit choice rules...
bio-structural-biology-alphafold-predictions bioskills Access and analyze AlphaFold protein structure predictions. Use when predicted structures are needed for proteins without experimental structures,...
bio-structural-biology-modern-structure-prediction bioskills Predict protein structures using modern ML models including AlphaFold3, ESMFold, Chai-1, and Boltz-1. Use when predicting structures for novel prot...
bio-substructure-search bioskills Searches molecular libraries for substructure matches using SMARTS patterns with explicit handling of recursive SMARTS, ring membership, aromaticit...
bio-transcription-translation bioskills Transcribe DNA to RNA and translate to protein using Biopython. Use when converting between DNA, RNA, and protein sequences, finding ORFs, or using...
bio-virtual-screening bioskills Performs structure-based virtual screening using AutoDock Vina, SMINA, GNINA (CNN scoring), and DiffDock-L hybrid workflows with explicit choice ru...
adhd-daily-planner openclaw Time-blind friendly planning, executive function support, and daily structure for ADHD brains. Specializes in realistic time estimation, dopamine-a...
alphafold-database openclaw Access AlphaFold's 200M+ AI-predicted protein structures. Retrieve structures by UniProt ID, download PDB/mmCIF files, analyze confidence metrics (...
antibody-design-agent openclaw An advanced agent for de novo antibody design and optimization using state-of-the-art protein language models (MAGE, RFdiffusion).
bindingdb-database openclaw Query BindingDB for measured drug-target binding affinities (Ki, Kd, IC50, EC50). Search by target (UniProt ID), compound (SMILES/name), or pathoge...

...and 127 additional proteomics skills in the skills/kdense/, skills/openclaw/, skills/sciagent/ directories.


Single-Cell Analysis

144 skills — preprocessing, clustering, cell type annotation, trajectory inference, cell communication, multimodal integration.

View all 144 skills
Skill Source Description
bio-atac-seq-co-accessibility bioskills Infer cis-regulatory connections (peak-to-peak co-accessibility) from scATAC-seq using Cicero, ArchR getCoAccessibility, or SCENIC+. Use when linki...
bio-atac-seq-deep-learning-atac bioskills Sequence-based deep learning for ATAC-seq using chromBPNet, BPNet, scBasset, or EnFormer. Use when correcting Tn5 bias with neural networks beyond...
bio-atac-seq-enhancer-gene-linking bioskills Predict enhancer-gene regulatory connections from ATAC-seq using ABC, ENCODE-rE2G, HiChIP, or Cicero. Use when linking distal enhancers to target g...
bio-atac-seq-motif-deviation bioskills Analyze TF motif accessibility variability across samples or single cells using chromVAR. Use when identifying TF motifs whose accessibility correl...
bio-atac-seq-single-cell-atac bioskills Process and analyze single-cell ATAC-seq data with Signac, ArchR, SnapATAC2, or Cell Ranger ATAC. Use when handling 10X scATAC or 10X Multiome (pai...
bio-causal-genomics-heritability-partitioning bioskills Estimate SNP heritability and partition it across functional annotations, cell types, and loci from GWAS summary statistics or individual-level gen...
bio-chipseq-chromatin-state-segmentation bioskills Segments the genome into chromatin states from combinatorial histone modification and chromatin factor ChIP-seq data. Uses ChromHMM (multivariate H...
bio-chipseq-peak-annotation bioskills Annotates ChIP-seq peaks to genomic features, nearest genes, ENCODE candidate cis-regulatory elements (cCREs), and regulatory domains. Uses ChIPsee...
bio-clip-seq-stamp-antibody-free bioskills Profiles RNA-binding protein targets without antibody or UV crosslinking using STAMP (APOBEC1-RBP fusion, C-to-U editing), scSTAMP (single-cell), T...
bio-crispr-screens-combinatorial-screens bioskills Designs and analyzes combinatorial CRISPR screens covering paired-Cas9 (Big Papi, Najm 2018), enhanced AsCas12a multiplex (enCas12a, DeWeirdt 2021)...
bio-crispr-screens-perturb-seq-analysis bioskills Analyzes single-cell pooled CRISPR screens (Perturb-seq, CROP-seq, Perturb-CITE-seq, ECCITE-seq, multiome) where each cell carries an sgRNA and a s...
bio-data-visualization-dimensionality-reduction-plots bioskills Produce and interpret PCA, t-SNE, UMAP, and PHATE plots for high-dimensional omics data with rigor about which method preserves what (variance, loc...
bio-data-visualization-matplotlib-fundamentals bioskills Build publication-quality figures with matplotlib using the object-oriented Figure/Axes API, constrained_layout, rcParams customization, TrueType (...
bio-expression-matrix-normalization bioskills Normalize and transform RNA-seq count matrices for differential expression, visualization, and clustering. Covers between-sample (TMM, RLE, upper q...
bio-expression-matrix-sparse-handling bioskills Work with sparse matrices for memory-efficient storage of count data. Use when dealing with single-cell data or large bulk RNA-seq datasets where m...
bio-flow-cytometry-clustering-phenotyping bioskills Unsupervised clustering and cell type identification for flow/mass cytometry. Covers FlowSOM, Phenograph, and CATALYST workflows. Use when discover...
bio-flow-cytometry-doublet-detection bioskills Detect and remove doublets from flow and mass cytometry data. Covers FSC/SSC gating and computational doublet detection methods. Use when filtering...
bio-flow-cytometry-doublet-detection bioskills Detect and remove doublets from flow and mass cytometry data. Covers FSC/SSC gating and computational doublet detection methods. Use when filtering...
bio-gene-regulatory-networks-coexpression-networks bioskills Build weighted gene co-expression networks to identify modules of co-regulated genes and relate them to phenotypes using WGCNA and CEMiTool. Detect...
bio-gene-regulatory-networks-multiomics-grn bioskills Build enhancer-driven gene regulatory networks by integrating single-cell RNA-seq and ATAC-seq data using SCENIC+ to identify eRegulons linking tra...
bio-gene-regulatory-networks-scenic-regulons bioskills Infer gene regulatory networks and identify transcription factor regulons from single-cell RNA-seq data using pySCENIC. Discovers co-expression mod...
bio-imaging-mass-cytometry-cell-segmentation bioskills Cell segmentation from multiplexed tissue images. Covers deep learning (Cellpose, Mesmer) and classical approaches for nuclear and whole-cell segme...
bio-imaging-mass-cytometry-interactive-annotation bioskills Interactive cell type annotation for IMC data. Covers napari-based annotation, marker-guided labeling, training data generation, and annotation val...
bio-imaging-mass-cytometry-phenotyping bioskills Cell type assignment from marker expression in IMC data. Covers manual gating, clustering, and automated classification approaches. Use when assign...
bio-imaging-mass-cytometry-spatial-analysis bioskills Spatial analysis of cell neighborhoods and interactions in IMC data. Covers neighbor graphs, spatial statistics, and interaction testing. Use when...
bio-machine-learning-atlas-mapping bioskills Maps query single-cell data to reference atlases using scArches transfer learning with scVI and scANVI models. Transfers cell type labels without r...
bio-methylation-dmr-detection bioskills Differentially methylated region (DMR) detection using methylKit tiles, bsseq BSmooth, and DMRcate. Use when identifying contiguous genomic regions...
bio-read-qc-umi-processing bioskills Extract, process, and deduplicate reads using Unique Molecular Identifiers (UMIs) with umi_tools. Use when library prep includes UMIs and accurate...
bio-single-cell-batch-integration bioskills Integrate multiple scRNA-seq samples/batches using Harmony, scVI, Seurat anchors, and fastMNN. Remove technical variation while preserving biologic...
bio-single-cell-cell-annotation bioskills Automated cell type annotation using reference-based methods including CellTypist, scPred, SingleR, and Azimuth for consistent, reproducible cell l...
bio-single-cell-cell-communication bioskills Infer cell-cell communication networks from scRNA-seq data using CellChat, NicheNet, and LIANA for ligand-receptor interaction analysis. Use when i...
bio-single-cell-clustering bioskills Dimensionality reduction and clustering for single-cell RNA-seq using Seurat (R) and Scanpy (Python). Use for running PCA, computing neighbors, clu...
bio-single-cell-data-io bioskills Read, write, and create single-cell data objects using Seurat (R) and Scanpy (Python). Use for loading 10X Genomics data, importing/exporting h5ad...
bio-single-cell-doublet-detection bioskills Detect and remove doublets (multiple cells captured in one droplet) from single-cell RNA-seq data. Uses Scrublet (Python), DoubletFinder (R), and s...
bio-single-cell-doublet-detection bioskills Detect and remove doublets (multiple cells captured in one droplet) from single-cell RNA-seq data. Uses Scrublet (Python), DoubletFinder (R), and s...
bio-single-cell-lineage-tracing bioskills Reconstruct cell lineage trees from CRISPR barcode tracing or mitochondrial mutations. Use when studying clonal dynamics, cell fate decisions, or d...
bio-single-cell-markers-annotation bioskills Find marker genes and annotate cell types in single-cell RNA-seq using Seurat (R) and Scanpy (Python). Use for differential expression between clus...
bio-single-cell-metabolite-communication bioskills Analyze metabolite-mediated cell-cell communication using MeboCost for metabolic signaling inference between cell types. Predict metabolite secreti...
bio-single-cell-multimodal-integration bioskills Analyze multi-modal single-cell data (CITE-seq, Multiome, spatial). Use when working with data that measures multiple modalities per cell like RNA...
bio-single-cell-perturb-seq bioskills Analyze Perturb-seq and CROP-seq CRISPR screening data integrated with scRNA-seq. Use when identifying gene function through pooled genetic perturb...

...and 104 additional single-cell analysis skills in the skills/openclaw/, skills/bioskills/, skills/sciagent/ directories.


Biology and AI

236 skills — medical AI, clinical decision support, drug discovery, general biological tools.

View all 236 skills
Skill Source Description
bio-flow-cytometry-bead-normalization bioskills Bead-based normalization for CyTOF and high-parameter flow cytometry. Covers EQ bead normalization, signal drift correction, and batch normalizatio...
bio-flow-cytometry-fcs-handling bioskills Read and manipulate Flow Cytometry Standard (FCS) files. Covers loading data, accessing parameters, and basic data exploration. Use when loading an...
bio-immunoinformatics-tcr-epitope-binding bioskills Predict TCR-epitope specificity using ERGO-II and deep learning models for T-cell receptor antigen recognition. Match TCRs to their cognate epitope...
bio-molecular-descriptors bioskills Calculates molecular fingerprints (ECFP/Morgan, FCFP, MACCS, RDKit, AtomPair, TopologicalTorsion, Avalon, MAP4, MHFP6) and physicochemical descript...
bio-phylo-divergence-dating bioskills Estimate divergence times using molecular clock models with BEAST2, MCMCTree, and TreePL. Use when dating speciation events, calibrating phylogenie...
bio-phylo-species-trees bioskills Estimate species trees using coalescent methods including ASTRAL-III, wASTRAL, ASTRAL-Pro, SVDQuartets, and BPP. Use when multi-locus data shows ge...
bio-phylo-tree-io bioskills Read, write, and convert phylogenetic tree files using Biopython Bio.Phylo. Use when parsing Newick, Nexus, PhyloXML, or NeXML tree formats, conver...
bio-reporting-quarto-reports bioskills Build reproducible scientific documents, presentations, and websites with Quarto supporting R, Python, Julia, and Observable JS. Use when creating...
bio-ribo-seq-ribosome-stalling bioskills Detect ribosome pausing and stalling sites from Ribo-seq data at codon resolution. Use when studying translational regulation, identifying pause si...
aav-vector-design-agent openclaw AI-powered adeno-associated virus (AAV) vector design for gene therapy including capsid engineering, promoter selection, and tropism optimization.
ai-analyzer openclaw AI驱动的综合健康分析系统,整合多维度健康数据、识别异常模式、预测健康风险、提供个性化建议。支持智能问答和AI健康报告生成。
bayesian-optimizer openclaw Bayesian Optimize
biokernel openclaw Biomedical OS Core & MCP Server
biologist-analyst openclaw Analyzes living systems and biological phenomena through biological lens using evolution, molecular biology, ecology, and systems biology framework...
biomcp-server openclaw MCP bio bridge
brainstorming openclaw You MUST use this before any creative work - creating features, building components, adding functionality, or modifying behavior. Explores user int...
cellagent-annotation openclaw Cell tagger
chemist-analyst openclaw Analyzes events through chemistry lens using molecular structure, reaction mechanisms, thermodynamics, kinetics, and analytical techniques (spectro...
computational-pathology-agent openclaw Analyze Whole Slide Images (WSI) for digital pathology, including tissue segmentation and feature extraction.
crisis-response-protocol openclaw Handle mental health crisis situations in AI coaching safely. Use when implementing crisis detection, safety protocols, emergency escalation, or su...
crispr-guide-design openclaw Guide foundry
data-transform openclaw Transform, clean, reshape, and preprocess data using pandas and numpy. Works with ANY LLM provider (GPT, Gemini, Claude, etc.).
differentiation-schemes openclaw Select and apply numerical differentiation schemes for PDE/ODE discretization. Use when choosing finite difference/volume/spectral schemes, buildin...
dispatching-parallel-agents openclaw Use when facing 2+ independent tasks that can be worked on without shared state or sequential dependencies
emergency-card openclaw 生成紧急情况下快速访问的医疗信息摘要卡片。当用户需要旅行、就诊准备、紧急情况或询问"紧急信息"、"医疗卡片"、"急救信息"时使用此技能。提取关键信息(过敏、用药、急症、植入物),支持多格式输出(JSON、文本、二维码),用于急救或快速就医。
epidemiologist-analyst openclaw Analyzes disease patterns and health events through epidemiological lens using surveillance systems, outbreak investigation methods, and disease mo...
executing-plans openclaw Use when you have a written implementation plan to execute in a separate session with review checkpoints
family-health-analyzer openclaw 分析家族病史、评估遗传风险、识别家庭健康模式、提供个性化预防建议
fhir-developer-skill openclaw FHIR API development guide for building healthcare endpoints. Use when: (1) Creating FHIR REST endpoints (Patient, Observation, Encounter, Conditio...
find-skills openclaw Helps users discover and install agent skills when they ask questions like "how do I do X", "find a skill for X", "is there a skill that can...", o...
fitness-analyzer openclaw 分析运动数据、识别运动模式、评估健身进展,并提供个性化训练建议。支持与慢性病数据的关联分析。
goal-analyzer openclaw 分析健康目标数据、识别目标模式、评估目标进度,并提供个性化目标管理建议。支持与营养、运动、睡眠等健康数据的关联分析。
grief-companion openclaw Compassionate bereavement support, memorial creation, grief education, and healing journey guidance. Specializes in understanding grief stages, cre...
health-trend-analyzer openclaw 分析一段时间内健康数据的趋势和模式。关联药物、症状、生命体征、化验结果和其他健康指标的变化。识别令人担忧的趋势、改善情况,并提供数据驱动的洞察。当用户询问健康趋势、模式、随时间的变化或"我的健康状况有什么变化?"时使用。支持多维度分析(体重/BMI、症状、药物依从性、化验结果、情绪睡眠),相关...
hipaa-compliance openclaw Ensure HIPAA compliance when handling PHI (Protected Health Information). Use when writing code that accesses user health data, check-ins, journal...
kragen-knowledge-graph openclaw Graph-RAG Solver
leads-literature-mining openclaw Review Automator
medical-imaging-review openclaw Write comprehensive literature reviews for medical imaging AI research. Use when writing survey papers, systematic reviews, or literature analyses...
mental-health-analyzer openclaw 分析心理健康数据、识别心理模式、评估心理健康状况、提供个性化心理健康建议。支持与睡眠、运动、营养等其他健康数据的关联分析。
mesh-generation openclaw Plan and evaluate mesh generation for numerical simulations. Use when choosing grid resolution, checking aspect ratios/skewness, estimating mesh qu...

...and 196 additional biology and ai skills in the skills/nobel/, skills/openclaw/, skills/neuroclaw/ directories.


Clinical and Medical

152 skills — EHR analysis, clinical trial design, drug interactions, precision medicine, adverse event detection.

View all 152 skills
Skill Source Description
bio-admet-prediction bioskills Predicts ADMET properties using ADMETlab 3.0 (119 endpoints with uncertainty), ADMET-AI, DeepChem MolNet, and chemprop D-MPNN with explicit handlin...
bio-clinical-biostatistics-bayesian-trials bioskills Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtur...
bio-clinical-biostatistics-cdisc-data bioskills Reads, validates, and prepares CDISC SDTM and ADaM clinical trial data for analysis. Covers SDTM domain joins (DM, AE, EX, VS, LB, DS), ADaM archit...
bio-clinical-biostatistics-effect-measures bioskills Computes and interprets treatment effect measures (OR, RR, RD, HR, NNT) with calibrated confidence intervals (Wilson, Newcombe, Miettinen-Nurminen,...
bio-clinical-biostatistics-logistic-regression bioskills Performs logistic regression for clinical trial outcomes (binary, ordinal, multinomial) with marginal-vs-conditional estimand reporting per FDA 202...
bio-clinical-biostatistics-missing-data bioskills Implements missing-data sensitivity analyses for confirmatory clinical trials including MMRM under MAR (with Kenward-Roger correction), reference-b...
bio-clinical-biostatistics-multiplicity-graphical bioskills Implements multiplicity control for confirmatory clinical trials using graphical procedures (Bretz-Maurer-Hommel), gatekeeping (parallel, serial, m...
bio-clinical-biostatistics-subgroup-analysis bioskills Performs subgroup and heterogeneous treatment effect (HTE) analyses for clinical trials. Covers Mantel-Haenszel pooling, Breslow-Day, interaction t...
bio-clinical-biostatistics-trial-reporting bioskills Prepares statistical reports for clinical trials following CONSORT 2025, SPIRIT 2025, ICH E9(R1) estimands, and FDA 2023 covariate adjustment guida...
bio-clinical-databases-polygenic-risk bioskills Constructs and validates polygenic risk scores using LDpred2-auto, SBayesRC, MegaPRS, PRS-CS, PROSPER, MUSSEL, BridgePRS, JointPRS, PRSmix, or PGS...
bio-covalent-design bioskills Designs covalent inhibitors and warheads targeting cysteine (most common, 98% of covalent drugs), lysine, serine, threonine, tyrosine, and aspartat...
bio-systems-biology-gene-essentiality bioskills Perform in silico gene knockout analysis and synthetic lethality screens using COBRApy single and double deletions. Predict essential genes and ide...
bio-workflows-clinical-trial-pipeline bioskills End-to-end clinical trial analysis workflow from CDISC SDTM/ADaM loading through ICH E9(R1) estimand-driven primary analysis to CONSORT 2025 regula...
bio-workflows-outbreak-pipeline bioskills End-to-end outbreak investigation from pathogen isolates to transmission networks. Orchestrates MLST typing, AMR surveillance, phylodynamic dating,...
agentd-drug-discovery openclaw Use the AgentD workflow to mine evidence, design molecules, and rank candidates with SAR plus ADMET annotations for early drug discovery tasks.
autonomous-oncology-agent openclaw Precision Oncology
biomedical-search openclaw Complete biomedical information search combining PubMed, preprints, clinical trials, and FDA drug labels. Powered by Valyu semantic search.
cancer-metabolism-agent openclaw AI-powered analysis of cancer metabolic reprogramming including Warburg effect, glutamine addiction, lipid metabolism, and metabolic vulnerabilitie...
cart-design-optimizer-agent openclaw AI-guided CAR-T cell design for solid tumors using antigen prioritization, safety-by-design architectures, and exhaustion-resistant engineering.
cellular-senescence-agent openclaw AI-powered analysis of cellular senescence for aging research, cancer therapy response, and senolytic drug development.
chatehr-clinician-assistant openclaw EHR Chat Assistant
chematagent-drug-discovery openclaw Chemical Lab Agent
chemcrow-drug-discovery openclaw An LLM chemistry agent with expert-designed tools for organic synthesis, drug discovery, and materials design.
chemical-property-lookup openclaw Compute RDKit-driven molecular properties (MW, logP, TPSA, QED, Lipinski) for a SMILES string to support downstream drug discovery tools.
chromosomal-instability-agent openclaw AI-powered analysis of chromosomal instability (CIN) signatures for cancer prognosis, immunotherapy response prediction, and therapeutic vulnerabil...
clinical-diagnostic-reasoning openclaw Identify and counteract cognitive biases in medical decision-making through systematic error analysis and contextual algorithm application. For dia...
clinical-trial-protocol-skill openclaw Generate clinical trial protocols for medical devices or drugs. This skill should be used when users say "Create a clinical trial protocol", "Gener...
clinical-trials-search openclaw Search ClinicalTrials.gov with natural language queries. Find clinical trials, enrollment, and outcomes using Valyu semantic search.
clinicaltrials-database openclaw Query ClinicalTrials.gov via API v2. Search trials by condition, drug, location, status, or phase. Retrieve trial details by NCT ID, export data, f...
ctdna-dynamics-mrd-agent openclaw AI-powered circulating tumor DNA dynamics analysis for molecular residual disease detection, treatment response monitoring, and early relapse predi...
cytokine-storm-analysis-agent openclaw AI-powered cytokine release syndrome (CRS) and cytokine storm analysis for prediction, monitoring, and management in immunotherapy and infectious d...
datacommons-client openclaw Work with Data Commons, a platform providing programmatic access to public statistical data from global sources. Use this skill when working with d...
drug-discovery-search openclaw End-to-end drug discovery platform combining ChEMBL compounds, DrugBank, targets, and FDA labels. Natural language powered by Valyu.
drug-interaction-checker openclaw Checks for potential drug-drug interactions (DDIs) between a list of medications.
drug-labels-search openclaw Search FDA drug labels with natural language queries. Official drug information, indications, and safety data via Valyu.
drugbank-search openclaw Search DrugBank comprehensive drug database with natural language queries. Drug mechanisms, interactions, and safety data powered by Valyu.
exosome-ev-analysis-agent openclaw AI-powered extracellular vesicle and exosome analysis for cancer biomarker discovery, liquid biopsy applications, and intercellular communication p...
immune-checkpoint-combination-agent openclaw AI-powered analysis for predicting optimal immune checkpoint inhibitor combinations based on tumor microenvironment, biomarkers, and molecular prof...
liquid-biopsy-analytics-agent openclaw Comprehensive analysis of liquid biopsy data (ctDNA, CTCs) for cancer detection, MRD monitoring, and response tracking.
medical-entity-extractor openclaw Extract medical entities (symptoms, medications, lab values, diagnoses) from patient messages.

...and 112 additional clinical and medical skills in the skills/drugclaw/, skills/openclaw/, skills/sciagent/ directories.


Transcriptomics

97 skills — RNA-seq full pipeline, differential expression, alternative splicing, lncRNA, small RNA.

View all 97 skills
Skill Source Description
bio-atac-seq-differential-accessibility bioskills Identify differentially accessible chromatin regions across conditions using DiffBind, csaw, DESeq2, or edgeR. Use when comparing ATAC-seq accessib...
bio-chipseq-differential-binding bioskills Identifies differentially bound ChIP-seq regions between conditions using DiffBind, csaw (sliding windows), DESeq2/edgeR/PyDESeq2 on count matrices...
bio-chipseq-spike-in-normalization bioskills Normalizes ChIP-seq data using exogenous spike-in (ChIP-Rx with Drosophila chromatin per Orlando 2014 / Egan 2016; E. coli carryover for CUT&RUN/CU...
bio-clip-seq-ago-clip-mirna-targets bioskills Identify direct miRNA-target interactions from AGO HITS-CLIP, AGO-CLEAR-CLIP (chimeric reads), HEAP (Halo-Ago2 mouse), chimeric eCLIP / miR-eCLIP (...
bio-clip-seq-binding-site-annotation bioskills Annotate CLIP-seq peaks or crosslink sites to RNA features (5'UTR, CDS, 3'UTR, intron, splice junction, snoRNA, tRNA, ncRNA, repeat elements) with...
bio-clip-seq-differential-clip bioskills Identify differentially bound regions across CLIP-seq conditions (knockdown vs control, treatment vs vehicle, disease vs healthy) using DEWSeq (sli...
bio-codon-usage bioskills Analyze codon usage, calculate CAI (Codon Adaptation Index), and examine synonymous codon bias using Biopython. Use when analyzing coding sequences...
bio-crispr-screens-batch-correction bioskills Batch effect correction for CRISPR screens covering ComBat empirical-Bayes, RUV, SVA, control-sgRNA normalization, and the model-based alternative...
bio-crispr-screens-batch-correction bioskills Batch effect correction for CRISPR screens covering ComBat empirical-Bayes, RUV, SVA, control-sgRNA normalization, and the model-based alternative...
bio-data-visualization-network-visualization bioskills Visualize biological networks (PPI, gene-regulatory, co-expression, pathway) with layout algorithm choice (ForceAtlas2, Fruchterman-Reingold, Kamad...
bio-data-visualization-volcano-and-ma-plots bioskills Build volcano and MA plots from differential-expression / association results with LFC shrinkage, FDR-adjusted thresholds, sensible label placement...
bio-de-deseq2-basics bioskills Perform differential expression analysis using DESeq2 in R/Bioconductor. Use for analyzing RNA-seq count data, creating DESeqDataSet objects, runni...
bio-de-edger-basics bioskills Perform differential expression analysis using edgeR in R/Bioconductor. Use for analyzing RNA-seq count data with the quasi-likelihood F-test frame...
bio-de-results bioskills Extract, filter, annotate, and export differential expression results from DESeq2 or edgeR. Use for identifying significant genes, applying multipl...
bio-differential-expression-batch-correction bioskills Remove batch effects from RNA-seq data using ComBat, ComBat-Seq, limma removeBatchEffect, and SVA for unknown batch variables. Use when correcting...
bio-differential-expression-batch-correction bioskills Remove batch effects from RNA-seq data using ComBat, ComBat-Seq, limma removeBatchEffect, and SVA for unknown batch variables. Use when correcting...
bio-differential-expression-timeseries-de bioskills Analyze time-series RNA-seq data using limma voom with splines, maSigPro, and ImpulseDE2. Identify genes with dynamic expression patterns. Use when...
bio-differential-splicing bioskills Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial...
bio-epitranscriptomics-m6a-differential bioskills Identify differential m6A methylation between conditions from MeRIP-seq. Use when comparing epitranscriptomic changes between treatment groups or c...
bio-epitranscriptomics-m6a-peak-calling bioskills Call m6A peaks from MeRIP-seq IP vs input comparisons. Use when identifying m6A modification sites from methylated RNA immunoprecipitation data.
bio-epitranscriptomics-m6anet-analysis bioskills Detect m6A modifications from Oxford Nanopore direct RNA sequencing using m6Anet. Use when analyzing epitranscriptomic modifications from long-read...
bio-expression-matrix-counts-ingest bioskills Load gene expression count matrices from various formats including CSV, TSV, featureCounts, Salmon, kallisto, and 10X. Use when importing quantific...
bio-flow-cytometry-differential-analysis bioskills Differential abundance and state analysis for cytometry data. Compare cell populations between conditions using statistical methods. Use when testi...
bio-gene-regulatory-networks-differential-networks bioskills Compare gene regulatory and co-expression networks between biological conditions to identify rewired regulatory relationships using DiffCorr. Detec...
bio-gene-regulatory-networks-perturbation-simulation bioskills Simulate transcription factor perturbation effects on cell state using CellOracle, which integrates GRN inference with in silico knockout and overe...
bio-geo-data bioskills Query and download from NCBI Gene Expression Omnibus (GEO) and EMBL-EBI's BioStudies/ArrayExpress mirror. Use when finding expression datasets, nav...
bio-immunoinformatics-immunogenicity-scoring bioskills Score and prioritize neoantigens and epitopes for immunogenicity using multi-factor models combining MHC binding, processing, expression, and seque...
bio-isoform-switching bioskills Analyzes differential transcript usage (DTU) and isoform switches with functional consequence prediction (NMD via 50nt rule, ORF disruption, protei...
bio-metabolomics-statistical-analysis bioskills Statistical analysis for metabolomics data. Covers preprocessing (log2 transformation, normalization), limma moderated testing with empirical Bayes...
bio-methylation-differential-cpg bioskills Per-CpG differential methylation testing from bisulfite sequencing count data or beta-value matrices. Covers beta and M-value computation, coverage...
bio-microbiome-differential-abundance bioskills Differential abundance testing for microbiome data using compositionally-aware methods like ALDEx2, ANCOM-BC2, and MaAsLin2. Use when identifying t...
bio-microbiome-differential-abundance bioskills Differential abundance testing for microbiome data using compositionally-aware methods like ALDEx2, ANCOM-BC2, and MaAsLin2. Use when identifying t...
bio-multi-omics-mofa-integration bioskills Multi-Omics Factor Analysis (MOFA2) for unsupervised integration of multiple data modalities. Identifies shared and view-specific sources of variat...
bio-pathway-go-enrichment bioskills Gene Ontology over-representation analysis using clusterProfiler enrichGO. Use when identifying biological functions enriched in a gene list from d...
bio-pathway-gsea bioskills Gene Set Enrichment Analysis using clusterProfiler gseGO and gseKEGG. Use when analyzing ranked gene lists to find coordinated expression changes i...
bio-proteomics-differential-abundance bioskills Statistical testing for differentially abundant proteins between conditions. Covers preprocessing (log2 transformation, normalization), limma and D...
bio-proteomics-differential-abundance bioskills Statistical testing for differentially abundant proteins between conditions. Covers preprocessing (log2 transformation, normalization), limma and D...
bio-reverse-complement bioskills Generate reverse complements and complements of DNA/RNA sequences using Biopython. Use when working with opposite strands, primer design, or conver...
bio-ribo-seq-translation-efficiency bioskills Calculate translation efficiency (TE) as the ratio of ribosome occupancy to mRNA abundance. Use when comparing translational regulation between con...
bio-rna-quantification-tximport-workflow bioskills Import transcript-level quantifications from Salmon/kallisto into R for gene-level analysis with DESeq2/edgeR using tximport or tximeta. Use when i...

...and 57 additional transcriptomics skills in the skills/bioskills/, skills/openclaw/, skills/omicsclaw/ directories.


Database Query

63 skills — UniProt, PDB, KEGG, Reactome, GEO, ClinVar, Ensembl, STRING.

View all 63 skills
Skill Source Description
bio-batch-downloads bioskills Download large datasets from NCBI efficiently using EPost, history server, batching, rate limiting, and retry logic. Use when bulk-fetching tens of...
bio-data-visualization-ggplot2-fundamentals bioskills Build publication-quality figures in R with ggplot2 using the grammar of graphics (data + aesthetics + geometries + scales + facets + themes) with...
bio-motif-search bioskills Find patterns, motifs, and subsequences in biological sequences using Biopython. Use when searching for transcription factor binding sites, regulat...
bio-restriction-sites bioskills Find restriction enzyme cut sites in DNA sequences using Biopython Bio.Restriction. Search with single enzymes, batches of enzymes, or commercially...
bio-retrosynthesis bioskills Performs retrosynthetic planning using AiZynthFinder (MCTS, template-based), Chemformer (template-free transformer), ASKCOS, and emerging RetroSynF...
biomni-general-agent openclaw Use the local Biomni checkout to orchestrate its 150+ biomedical tools, databases, and know-how workflows for complex research questions.
biomni-research-agent openclaw Bio-Research Generalist
chembl-search openclaw Search ChEMBL bioactive molecules database with natural language queries. Find compounds and assay data with Valyu semantic search.
deep-research openclaw Execute autonomous multi-step deep research on any topic. Use when the user asks for comprehensive research, literature reviews, competitive analys...
deep-research-swarm openclaw Multi-agent research literature analysis
knowledge-synthesis openclaw Combines search results from multiple sources into coherent, deduplicated answers with source attribution. Handles confidence scoring based on fres...
labstep openclaw Interact with the Labstep electronic lab notebook API using labstepPy. Query experiments, protocols, resources, inventory, and other lab entities.
literature-search openclaw Comprehensive scientific literature search across PubMed, arXiv, bioRxiv, medRxiv. Natural language queries powered by Valyu semantic search.
mcpmed-bioinformatics-server openclaw Model Context Protocol (MCP) server for bioinformatics web services like GEO, STRING, and UCSC Cell Browser.
medrxiv-search openclaw Search medRxiv medical preprints with natural language queries. Powered by Valyu semantic search.
nonlinear-solvers openclaw Select and configure nonlinear solvers for f(x)=0 or min F(x). Use for Newton methods, quasi-Newton (BFGS, L-BFGS), Broyden, Anderson acceleration,...
patents-search openclaw Search global patents with natural language queries. Prior art, patent landscapes, and innovation tracking via Valyu.
perplexity-search openclaw Perform AI-powered web searches with real-time information using Perplexity models via LiteLLM and OpenRouter. This skill should be used when condu...
pubmed-search openclaw Search PubMed for scientific literature. Use when the user asks to find papers, search literature, look up research, find publications, or asks abo...
research-grants openclaw Write competitive research proposals for NSF, NIH, DOE, and DARPA. Agency-specific formatting, review criteria, budget preparation, broader impacts...
research-literature openclaw Research Literature agent for healthcare workflows.
research-lookup openclaw Look up current research information using Perplexity's Sonar Pro Search or Sonar Reasoning Pro models through OpenRouter. Automatically selects th...
scientific-problem-selection openclaw This skill should be used when scientists need help with research problem selection, project ideation, troubleshooting stuck projects, or strategic...
search-strategy openclaw Query decomposition and multi-source search orchestration. Breaks natural language questions into targeted searches per source, translates queries...
virtual-lab-agent openclaw AI-powered virtual laboratory orchestrating multi-agent scientific research teams for autonomous hypothesis generation, experimental design, and va...
biorxiv-database sciagent Query bioRxiv/medRxiv preprints via REST API. Search by DOI, category, or date range; retrieve metadata (title, abstract, authors, category, DOI, v...
geopandas-geospatial sciagent Geospatial vector analysis extending pandas. Read/write spatial formats (Shapefile, GeoJSON, GeoPackage, Parquet, PostGIS), CRS handling, geometric...
plotly-interactive-visualization sciagent Interactive visualization with Plotly. 40+ chart types (scatter, line, heatmap, 3D, geographic) with hover, zoom, pan. Two APIs: Plotly Express (Da...
pymoo sciagent Python framework for single- and multi-objective optimization with evolutionary algorithms. Define vectorized objectives and constraints; solve wit...
scikit-learn-machine-learning sciagent Classical ML in Python: classification, regression, clustering, dim reduction, evaluation, tuning, preprocessing pipelines. Linear models, tree ens...
scikit-survival-analysis sciagent Time-to-event modeling with scikit-survival: Cox PH (elastic net), Random Survival Forests, Boosting, SVMs for censored data. C-index, Brier, time-...
uspto-database sciagent Access USPTO patent data via PatentsView REST API and Google Patents Public Data (BigQuery). Search by inventor, assignee, CPC, or keywords; downlo...
eqtl-catalogue-region-fetch clawbio Fetch a region of cis-eQTL summary statistics from EBI eQTL Catalogue v7+ via tabix-on-FTP. Use when an agent needs eQTL beta / SE / p-value for ev...
ncbi-datasets clawbio Download genomes, genes, virus sequences, and taxonomy data from NCBI using the datasets and dataformat CLI tools.
turingdb-graph clawbio Build, query, and analyse biomedical knowledge graphs in TuringDB, a columnar graph database with git-like versioning.
ukb-navigator clawbio Semantic search across UK Biobank's 12,000+ data fields and publications — find the right variables for your
bio-dataset-search bioclaw Step 3: Dataset search and task matching (数据集搜索与匹配)
bio-tools bioclaw Biology research tools reference. Always available inside agent containers.
aeon kdense This skill should be used for time series machine learning tasks including classification, regression, clustering, forecasting, anomaly detection,...
citation-management kdense Comprehensive citation management for academic research. Search Google Scholar and PubMed for papers, extract accurate metadata, validate citations...

...and 23 additional database query skills in the skills/kdense/, skills/labclaw/, skills/omics/ directories.


Multi-Omics Integration

69 skills — MOFA, DIABLO, single-cell multimodal, spatial transcriptomics.

View all 69 skills
Skill Source Description
bio-clinical-biostatistics-survival-analysis bioskills Performs time-to-event analysis for clinical trials including Cox proportional hazards regression with PH diagnostics, restricted mean survival tim...
bio-clinical-biostatistics-survival-analysis bioskills Performs time-to-event analysis for clinical trials including Cox proportional hazards regression with PH diagnostics, restricted mean survival tim...
bio-machine-learning-biomarker-discovery bioskills Selects informative features for biomarker discovery using Boruta all-relevant selection, mRMR minimum redundancy, and LASSO regularization. Use wh...
bio-machine-learning-model-validation bioskills Implements nested cross-validation and stratified splits for unbiased model evaluation on biomedical datasets. Prevents data leakage and overfittin...
bio-machine-learning-prediction-explanation bioskills Explains machine learning predictions on omics data using SHAP values and LIME for feature attribution. Identifies which genes or features drive cl...
bio-machine-learning-survival-analysis bioskills Analyzes time-to-event data using Kaplan-Meier curves, log-rank tests, and Cox proportional hazards regression with lifelines. Builds survival mode...
bio-machine-learning-survival-analysis bioskills Analyzes time-to-event data using Kaplan-Meier curves, log-rank tests, and Cox proportional hazards regression with lifelines. Builds survival mode...
bio-metabolomics-lipidomics bioskills Specialized lipidomics analysis for lipid identification, quantification, and pathway interpretation. Covers LC-MS lipidomics with LipidSearch, MS-...
bio-metabolomics-metabolite-annotation bioskills Metabolite identification from m/z and retention time. Covers database matching, MS/MS spectral matching, and confidence level assignment. Use when...
bio-metabolomics-normalization-qc bioskills Quality control and normalization for metabolomics data. Covers QC-based correction, batch effect removal, and data transformation methods. Use whe...
bio-metabolomics-targeted-analysis bioskills Targeted metabolomics analysis using MRM/SRM with standard curves. Covers absolute quantification, method validation, and quality assessment. Use w...
bio-multi-omics-mixomics-analysis bioskills Supervised and unsupervised multi-omics integration with mixOmics. Includes sPLS for pairwise integration and DIABLO for multi-block discriminant a...
bio-multi-omics-similarity-network bioskills Similarity Network Fusion (SNF) for patient stratification using multi-omics data. Integrates multiple data types into a unified patient similarity...
bio-data-visualization-specialized-omics-plots openclaw Reusable plotting functions for common omics visualizations. Custom ggplot2/matplotlib implementations of volcano, MA, PCA, enrichment dotplots, bo...
biomedical-data-analysis openclaw Omics data forge
dask openclaw Distributed computing for larger-than-RAM pandas/NumPy workflows. Use when you need to scale existing pandas/NumPy code beyond memory or across clu...
digital-twin-clinical-agent openclaw AI-powered patient digital twin creation for clinical trial simulation, treatment outcome prediction, and personalized medicine using real-world da...
ehr-fhir-integration openclaw Provides comprehensive tools for working with Electronic Health Records (EHR) using the HL7 FHIR standard.
infographics openclaw Create professional infographics using Nano Banana Pro AI with smart iterative refinement. Uses Gemini 3 Pro for quality review. Integrates researc...
labarchive-integration openclaw Electronic lab notebook API integration. Access notebooks, manage entries/attachments, backup notebooks, integrate with Protocols.io/Jupyter/REDCap...
latex-posters openclaw Create professional research posters in LaTeX using beamerposter, tikzposter, or baposter. Support for conference presentations, academic posters,...
medea-therapeutic-discovery openclaw An AI agent for therapeutic discovery that executes transparent, multi-step omics analyses including research planning, code execution, and literat...
multi-search-engine openclaw Multi search engine integration with 17 engines (8 CN + 9 Global). Supports advanced search operators, time filters, site search, privacy engines,...
numerical-integration openclaw Select and configure time integration methods for ODE/PDE simulations. Use when choosing explicit/implicit schemes, setting error tolerances, adapt...
opentrons-integration openclaw Lab automation platform for Flex/OT-2 robots. Write Protocol API v2 protocols, liquid handling, hardware modules (heater-shaker, thermocycler), lab...
pptx-posters openclaw Create research posters using HTML/CSS that can be exported to PDF or PPTX. Use this skill ONLY when the user explicitly requests PowerPoint/PPTX p...
pyzotero openclaw Interact with Zotero reference management libraries using the pyzotero Python client. Retrieve, create, update, and delete items, collections, tags...
seaborn openclaw Statistical visualization with pandas integration. Use for quick exploration of distributions, relationships, and categorical comparisons with attr...
tooluniverse-immunotherapy-response-prediction openclaw Predict patient response to immune checkpoint inhibitors (ICIs) using multi-biomarker integration. Given a cancer type, somatic mutations, and opti...
tooluniverse-metabolomics openclaw Comprehensive metabolomics research skill for identifying metabolites, analyzing studies, and searching metabolomics databases. Integrates HMDB (22...
wellally-tech openclaw Integrate digital health data sources (Apple Health, Fitbit, Oura Ring) and connect to WellAlly.tech knowledge base. Import external health device...
zarr-python openclaw Chunked N-D arrays for cloud storage. Compressed arrays, parallel I/O, S3/GCS integration, NumPy/Dask/Xarray compatible, for large-scale scientific...
brenda-database sciagent BRENDA Enzyme DB SOAP/REST queries: kinetic parameters (Km, Vmax, kcat, Ki), EC classes, substrate specificity, inhibitors, cofactors, organism dat...
kegg-pathway-analysis sciagent Guide to KEGG pathway enrichment for DEG results. Covers ORA vs GSEA, mandatory directionality splitting, KEGG organism codes, API failure handling...
latex-research-posters sciagent Research posters in LaTeX using beamerposter, tikzposter, or baposter. Layout, typography, color schemes, figure integration, accessibility, and QA...
libsbml-network-modeling sciagent Build, read, validate, modify SBML biological network models via the libSBML Python API. SBML Levels 1–3, reactions/kinetic laws, species, rules, F...
protocolsio-integration sciagent protocols.io REST API: search and fetch wet-lab, bioinformatics, and clinical protocols by keyword, DOI, or category, with steps, reagents, materia...
reactome-database sciagent Query Reactome pathways via REST: pathway queries, entity lookup, keyword search, gene list enrichment, hierarchy, cross-refs. Content + Analysis s...
database-access bioclaw_hub Workflow for retrieving public omics datasets, sequences, annotations, and literature-linked biological resources.
machine-learning-for-omics bioclaw_hub Workflow for predictive modeling, biomarker discovery, survival modeling, and explainability over omics-derived features.

...and 29 additional multi-omics integration skills in the skills/neuroclaw/, skills/kdense/, skills/bioclaw_hub/ directories.


Bioinformatics Utilities

86 skills — sequence analysis, BLAST, tool chains, pipeline management.

View all 86 skills
Skill Source Description
bio-batch-processing bioskills Process multiple sequence files in batch using Biopython. Use when working with many files, merging/splitting sequences, or automating file operati...
bio-compressed-files bioskills Read and write compressed sequence files (gzip, bzip2, BGZF) using Biopython. Use when working with .gz or .bz2 sequence files. Use BGZF for indexa...
bio-filter-sequences bioskills Filter and select sequences by criteria (length, ID, GC content, patterns) using Biopython. Use when subsetting sequences, removing unwanted record...
bio-flow-cytometry-compensation-transformation bioskills Spillover compensation and data transformation for flow cytometry. Covers compensation matrix calculation, application, and biexponential/arcsinh t...
bio-flow-cytometry-gating-analysis bioskills Manual and automated gating for defining cell populations in flow cytometry. Covers rectangular, polygon, and data-driven gates. Use when identifyi...
bio-fragment-analysis bioskills Analyzes cfDNA fragment size distributions and fragmentomics features using FinaleToolkit or Griffin. Extracts nucleosome positioning patterns, fra...
bio-fragment-analysis bioskills Analyzes cfDNA fragment size distributions and fragmentomics features using FinaleToolkit or Griffin. Extracts nucleosome positioning patterns, fra...
bio-hi-c-analysis-hic-data-io bioskills Load, convert, and manipulate Hi-C contact matrices using cooler format. Read .cool/.mcool files, convert from .hic format, access matrix data, and...
bio-hi-c-analysis-matrix-operations bioskills Balance, normalize, and transform Hi-C contact matrices using cooler and cooltools. Apply iterative correction (ICE), compute expected values, and...
bio-imaging-mass-cytometry-data-preprocessing bioskills Load and preprocess imaging mass cytometry (IMC) and MIBI data. Covers MCD/TIFF handling, hot pixel removal, and image normalization. Use when star...
bio-imaging-mass-cytometry-quality-metrics bioskills Quality metrics for IMC data including signal-to-noise, channel correlation, tissue integrity, and acquisition QC. Use when assessing data quality...
bio-primer-design-primer-basics bioskills Design PCR primers for a target sequence using primer3-py. Specify target regions, product size, melting temperature, and other constraints. Return...
bio-read-qc-quality-filtering bioskills Filter reads by quality scores, length, and N content using Trimmomatic and fastp. Apply sliding window trimming, remove low-quality bases from rea...
bio-restriction-enzyme-selection bioskills Select restriction enzymes by criteria using Biopython Bio.Restriction. Find enzymes that cut once, don't cut, produce specific overhangs, are comm...
bio-restriction-fragment-analysis bioskills Analyze restriction digest fragments using Biopython Bio.Restriction. Predict fragment sizes, get fragment sequences, simulate gel electrophoresis...
bio-restriction-fragment-analysis bioskills Analyze restriction digest fragments using Biopython Bio.Restriction. Predict fragment sizes, get fragment sequences, simulate gel electrophoresis...
bio-ribo-seq-orf-detection bioskills Detect and quantify translated ORFs from Ribo-seq data including uORFs and novel ORFs using RiboCode and ORFquant. Use when identifying translated...
bio-ribo-seq-ribosome-periodicity bioskills Validate Ribo-seq data quality by checking 3-nucleotide periodicity and calculating P-site offsets. Use when assessing library quality or determini...
bio-seq-objects bioskills Create and manipulate Seq, MutableSeq, and SeqRecord objects using Biopython. Use when creating sequences from strings, modifying sequence data in-...
bio-sequence-properties bioskills Calculate sequence properties like GC content, molecular weight, isoelectric point, and GC skew using Biopython. Use when analyzing sequence compos...
bio-sequence-slicing bioskills Slice, extract, and concatenate biological sequences using Biopython. Use when extracting subsequences, joining sequences, or manipulating sequence...
bio-sequence-statistics bioskills Calculate sequence statistics (N50, length distribution, GC content, summary reports) using Biopython. Use when analyzing sequence datasets, genera...
bone-marrow-ai-agent openclaw AI-powered bone marrow morphology analysis, cell classification, and hematologic disorder diagnosis using deep learning on aspirate and biopsy images.
chemistry-agent openclaw Autonomous chemical synthesis & analysis
coagulation-thrombosis-agent openclaw AI-powered analysis of coagulation disorders, thrombosis risk prediction, anticoagulation management, and platelet function assessment using machin...
convergence-study openclaw Spatial and temporal convergence analysis with Richardson extrapolation and Grid Convergence Index (GCI) for solution verification
crisis-detection-intervention-ai openclaw Detect crisis signals in user content using NLP, mental health sentiment analysis, and safe intervention protocols. Implements suicide ideation det...
data-stats-analysis openclaw Perform statistical tests, hypothesis testing, correlation analysis, and multiple testing corrections using scipy and statsmodels. Works with ANY L...
hrv-alexithymia-expert openclaw Heart rate variability biometrics and emotional awareness training. Expert in HRV analysis, interoception training, biofeedback, and emotional inte...
jungian-psychologist openclaw Expert in Jungian analytical psychology, depth psychology, shadow work, archetypal analysis, dream interpretation, active imagination, addiction/re...
numerical-stability openclaw Analyze and enforce numerical stability for time-dependent PDE simulations. Use when selecting time steps, choosing explicit/implicit schemes, diag...
pdf openclaw Comprehensive PDF manipulation toolkit for extracting text and tables, creating new PDFs, merging/splitting documents, and handling forms. When Cla...
performance-profiling openclaw Identify computational bottlenecks, analyze scaling behavior, estimate memory requirements, and receive optimization recommendations for any comput...
polars openclaw Fast in-memory DataFrame library for datasets that fit in RAM. Use when pandas is too slow but data still fits in memory. Lazy evaluation, parallel...
scikit-survival openclaw Comprehensive toolkit for survival analysis and time-to-event modeling in Python using scikit-survival. Use this skill when working with censored s...
statsmodels openclaw Statistical modeling toolkit. OLS, GLM, logistic, ARIMA, time series, hypothesis tests, diagnostics, AIC/BIC, for rigorous statistical inference an...
tooluniverse-image-analysis openclaw Production-ready microscopy image analysis and quantitative imaging data skill for colony morphometry, cell counting, fluorescence quantification,...
umap-learn openclaw UMAP dimensionality reduction. Fast nonlinear manifold learning for 2D/3D visualization, clustering preprocessing (HDBSCAN), supervised/parametric...
using-superpowers openclaw Use when starting any conversation - establishes how to find and use skills, requiring Skill tool invocation before ANY response including clarifyi...
usmle openclaw Prepare for US medical licensing exams with progress tracking, weak area analysis, question bank management, and residency match planning.

...and 46 additional bioinformatics utilities skills in the skills/neuroclaw/, skills/sciagent/, skills/kdense/ directories.


Visualization

48 skills — volcano plots, heatmaps, PCA/UMAP, interactive charts.

View all 48 skills
Skill Source Description
bio-copy-number-copy-ratio-segmentation bioskills Normalize read-depth copy-ratio profiles and segment them into copy-number regions using circular binary segmentation (CBS, DNAcopy), hidden Markov...
bio-data-visualization-color-palettes bioskills Select colormaps and qualitative palettes for scientific figures using perceptual-uniformity, color-vision-deficiency safety, and luminance-monoton...
bio-data-visualization-forest-funnel-plots bioskills Build forest plots (HR, OR, RR, beta-coefficient summaries with CIs) and funnel plots (meta-analysis publication-bias diagnostics) using forestplot...
bio-data-visualization-interactive-visualization bioskills Build interactive HTML/web visualizations with plotly (Python/R), bokeh (Python), and gganimate/plotly frames for animation, with awareness of curr...
bio-data-visualization-multipanel-figures bioskills Compose multi-panel publication figures with patchwork, cowplot, gridExtra (R), or matplotlib GridSpec/subfigures (Python) including shared axes/le...
bio-data-visualization-statistical-annotation bioskills Add p-value brackets, significance asterisks, and effect-size annotations to distribution plots using ggpubr, ggsignif, and statannotations with co...
bio-phylo-tree-visualization bioskills Draw and export phylogenetic trees using Biopython Bio.Phylo with matplotlib and modern alternatives. Use when creating tree figures, customizing c...
bio-primer-design-qpcr-primers bioskills Design qPCR primers and TaqMan/molecular beacon probes using primer3-py. Configure probe Tm, primer-probe spacing, and hydrolysis probe constraints...
bio-reporting-figure-export bioskills Exports publication-ready figures in various formats with proper resolution, sizing, and typography. Use when preparing figures for journal submiss...
bio-reporting-rmarkdown-reports bioskills Create reproducible bioinformatics analysis reports with R Markdown including code, results, and visualizations in HTML, PDF, or Word format. Use w...
bio-tcr-bcr-analysis-repertoire-visualization bioskills Create publication-quality visualizations of immune repertoire data including circos plots, clone tracking, diversity plots, and network graphs. Us...
bio-workflows-hic-pipeline bioskills End-to-end Hi-C analysis workflow from contact pairs to compartments, TADs, and loops. Covers cooler matrices, cooltools analysis, and visualizatio...
data-visualization-expert openclaw Generate insightful, publication-quality visualizations from complex datasets.
data-viz-plots openclaw Create publication-quality plots and visualizations using matplotlib and seaborn. Works with ANY LLM provider (GPT, Gemini, Claude, etc.).
linear-solvers openclaw Select and configure linear solvers for systems Ax=b in dense and sparse problems. Use when choosing direct vs iterative methods, diagnosing conver...
markdown-mermaid-writing openclaw Comprehensive markdown and Mermaid diagram writing skill. Use when creating any scientific document, report, analysis, or visualization. Establishe...
plotly openclaw Interactive visualization library. Use when you need hover info, zoom, pan, or web-embeddable charts. Best for dashboards, exploratory analysis, an...
post-processing openclaw Extract, analyze, and visualize simulation output data. Use for field extraction, time series analysis, line profiles, statistical summaries, deriv...
pytorch-lightning openclaw Deep learning framework (PyTorch Lightning). Organize PyTorch code into LightningModules, configure Trainers for multi-GPU/TPU, implement data pipe...
speech-pathology-ai openclaw Expert speech-language pathologist specializing in AI-powered speech therapy, phoneme analysis, articulation visualization, voice disorders, fluenc...
vaex openclaw Use this skill for processing and analyzing large tabular datasets (billions of rows) that exceed available RAM. Vaex excels at out-of-core DataFra...
cell-figure-guide sciagent Cell (Cell Press) figure preparation: resolution (300-1000 DPI), formats (TIFF/PDF), RGB color, Avenir/Arial fonts, uppercase panel labels, strict...
general-figure-guide sciagent Universal QA checklist for generated scientific plots: overlapping labels, clipped text, missing axes/legends, overcrowded data, and cross-journal...
matplotlib-scientific-plotting sciagent Low-level Python plotting for scientific figures: publication-quality line, scatter, bar, heatmap, contour, 3D; multi-panel layouts; fine control o...
napari-image-viewer sciagent Interactive viewer for microscopy. Displays 2D/3D/4D arrays as Image, Labels, Points, Shapes, Tracks layers; supports annotation, plugin analysis,...
networkx-graph-analysis sciagent Graph and network analysis toolkit. Four graph types (directed, undirected, multi-edge), centrality, shortest paths, community detection, generator...
pyimagej-fiji-bridge sciagent Python bridge to ImageJ2/Fiji for macros, plugins (Bio-Formats, TrackMate, Analyze Particles), NumPy↔ImagePlus/ImgLib2 exchange, and ImageJ Ops. Au...
scikit-image-processing sciagent Python image processing for microscopy and bioimage analysis. Read/write images, filter (Gaussian, median, LoG), segment (thresholding, watershed,...
statistical-significance-annotation sciagent Guide for annotating statistical significance (p-value asterisks) on comparison plots. Covers standard notation (ns, *, **, ***, ****), matplotlib...
reporting-and-figure-export bioclaw_hub Workflow for packaging analysis outputs into reproducible reports, clean tables, and publication-ready figure exports.
bio-figure-design bioclaw Step 6: Figure design (Figure 详细设计)
report-template bioclaw Publication-quality PDF report generation using Typst templates. Produces professional scientific reports with colored section bands, styled tables...
neuropixels-analysis kdense Neuropixels neural recording analysis. Load SpikeGLX/OpenEphys data, preprocess, motion correction, Kilosort4 spike sorting, quality metrics, Allen...
scientific-visualization kdense Meta-skill for publication-ready figures. Use when creating journal submission figures requiring multi-panel layouts, significance annotations, err...
shap kdense Model interpretability and explainability using SHAP (SHapley Additive exPlanations). Use this skill when explaining machine learning model predict...
generate_cell_analysis_charts labclaw Domain-specialized chart generator for cell biology video analysis outputs. Consumes structured JSON from analyze_lab_video_cell_behavior or compat...
generate_double_column_pdf_report labclaw Assembles experimental data, figures, methods, and results into a journal-style double-column PDF report. Uses reportlab or PyMuPDF for programmati...
hand-tracking-toolkit labclaw Facebook Research Hand Tracking Challenge Toolkit - evaluation and visualization tools for 3D hand tracking. Supports loading HOT3D data, computing...
hands-3d-pose labclaw High-quality 3D hand pose estimation for egocentric videos from ECCV 2024 (ap229997/hands). Provides 3D joint keypoints and skeleton visualization...
hot3d labclaw HOT3D (Hand-Object 3D Dataset) by Meta Facebook - multi-view egocentric hand and object 3D tracking for Aria/Quest smart glasses. State-of-the-art...

...and 8 additional visualization skills in the skills/omics/, skills/labclaw/, skills/medgeclaw/ directories.


Workflow Orchestration

38 skills — Snakemake, Nextflow, CWL, WDL.

View all 38 skills
Skill Source Description
bio-reporting-jupyter-reports bioskills Creates reproducible Jupyter notebooks for bioinformatics analysis with parameterization using papermill. Use when generating automated analysis re...
bio-workflow-management-cwl-workflows bioskills Create portable, standards-based bioinformatics pipelines with Common Workflow Language (CWL). Use when building workflows that need maximum portab...
bio-workflow-management-nextflow-pipelines bioskills Create scalable, containerized bioinformatics pipelines with Nextflow DSL2 supporting Docker, Singularity, and cloud execution. Use when building p...
bio-workflow-management-snakemake-workflows bioskills Build reproducible bioinformatics pipelines with Snakemake using rules, wildcards, and automatic dependency resolution. Use when creating Python-ba...
bio-workflow-management-wdl-workflows bioskills Create portable bioinformatics pipelines with Workflow Description Language (WDL) using Cromwell or miniwdl execution engines. Use when running GAT...
bio-workflows-crispr-editing-pipeline bioskills End-to-end CRISPR experiment design from target selection to delivery-ready constructs. Covers guide RNA design, off-target assessment, and special...
bio-workflows-cytometry-pipeline bioskills End-to-end flow cytometry workflow from FCS files to differential analysis. Orchestrates compensation, transformation, gating/clustering, and stati...
bio-workflows-imc-pipeline bioskills End-to-end imaging mass cytometry workflow from raw acquisitions to spatial cell analysis. Orchestrates image preprocessing, segmentation, phenotyp...
biomaster-workflows openclaw Pipeline maestro
care-coordination openclaw Care Coordination agent for healthcare workflows.
claims-appeals openclaw Claims Appeals agent for healthcare workflows.
fhir-development openclaw FHIR Development agent for healthcare workflows.
instrument-data-to-allotrope openclaw Convert laboratory instrument output files (PDF, CSV, Excel, TXT) to Allotrope Simple Model (ASM) JSON format or flattened 2D CSV. Use this skill w...
lab-results openclaw Lab Results agent for healthcare workflows.
pdf-processing-pro openclaw Production-ready PDF processing with forms, tables, OCR, validation, and batch operations. Use when working with complex PDF workflows in productio...
pylabrobot openclaw Laboratory automation toolkit for controlling liquid handlers, plate readers, pumps, heater shakers, incubators, centrifuges, and analytical equipm...
regulatory-drafting openclaw Regulatory Drafting agent for healthcare workflows.
scikit-learn openclaw Machine learning in Python with scikit-learn. Use when working with supervised learning (classification, regression), unsupervised learning (cluste...
simulation-orchestrator openclaw Orchestrate multi-simulation campaigns including parameter sweeps, batch jobs, and result aggregation. Use for running parameter studies, managing...
single-trajectory-analysis openclaw Guide to reproducing OmicVerse trajectory workflows spanning PAGA, Palantir, VIA, velocity coupling, and fate scoring notebooks.
histolab-wsi-processing sciagent WSI processing for digital pathology. Tissue detection, tile extraction (random, grid, score-based), filter pipelines for H&E/IHC. For dataset prep...
nextflow-workflow-engine sciagent Dataflow workflow engine for scalable bioinformatics pipelines. Defines processes (containerized tasks) connected by channels; runs local, HPC (SLU...
pylabrobot sciagent Hardware-agnostic Python liquid-handler library: portable scripts run on Hamilton STAR, Tecan Freedom EVO, Opentrons OT-2, or a simulator without v...
spikeinterface-electrophysiology sciagent Unified Python framework for extracellular electrophysiology. Load 20+ formats (SpikeGLX, OpenEphys, NWB, Intan, Maxwell, Blackrock), preprocess, r...
sequence-and-format-io bioclaw_hub Workflow for foundational sequence parsing, conversion, compression handling, and interval-aware file validation.
bioconductor-bridge clawbio Bioconductor package discovery, workflow recommendation, setup inspection, and starter code generation grounded
bio-manuscript-pipeline bioclaw End-to-end pipeline from structured research input to a full manuscript plan (一条龙 Pipeline)
skills-hub bioclaw Browse and install community skills from the BioClaw Skills Hub. Use when a user's task is not covered by built-in skills, or when the user asks ab...
polars kdense Fast in-memory DataFrame library for datasets that fit in RAM. Use when pandas is too slow but data still fits in memory. Lazy evaluation, parallel...
pydicom kdense Python library for working with DICOM (Digital Imaging and Communications in Medicine) files. Use this skill when reading, writing, or modifying me...
scikit-survival kdense Comprehensive toolkit for survival analysis and time-to-event modeling in Python using scikit-survival. Use this skill when working with censored s...
experiment-pipeline evoskills Guides structured 4-stage experiment execution with attempt budgets and gate conditions: Stage 1 initial implementation (reproduce baseline), Stage...
biomed-dispatch medgeclaw Dispatch biomedical research and data analysis tasks to Claude Code with K-Dense Scientific Skills. Use this skill when the user asks to run any bi...
git-workflows neuroclaw Advanced git operations beyond add/commit/push. Use when rebasing, bisecting bugs, using worktrees for parallel development, recovering with reflog...
hcppipeline-tool neuroclaw Use this skill whenever the user wants to perform high-quality, HCP-style preprocessing of multimodal MRI data (structural, functional, diffusion)...
bio-workflow-methods-docwriter omics Generate reproducible Methods documentation from workflow run artifacts (Nextflow/Snakemake/CWL), including exact commands, versions, parameters, Q...
Gene Panel Selection Workflow pantheon End-to-end workflow for gene panel design in scRNA-seq and spatial transcriptomics, that should be STRICTLY followed: dataset understanding + s...
nf-core Pipelines Skills Index pantheon Skills for using nf-core community pipelines to process omics data, from installation and configuration to running specific analysis pipelines.

Epigenomics

19 skills — ChIP-seq, ATAC-seq, DNA methylation, Hi-C, chromatin state.

View all 19 skills
Skill Source Description
bio-atac-seq-atac-qc bioskills ATAC-seq library quality control -- TSS enrichment, FRiP, fragment-size periodicity, library complexity (NRF/PBC1/PBC2), mitochondrial fraction, an...
bio-atac-seq-footprinting bioskills Detect transcription factor binding footprints in ATAC-seq using TOBIAS, HINT-ATAC, Wellington, or scprinter. Use when identifying bound TF sites w...
bio-chipseq-cut-and-run-tag bioskills Analyzes CUT&RUN (Skene Henikoff 2017) and CUT&Tag (Kaya-Okur 2019) chromatin profiling data. Handles SEACR vs MACS2 peak calling (with the btaf375...
bio-chipseq-motif-analysis bioskills Discovers de novo motifs and tests known motif enrichment in ChIP-seq, ATAC-seq, or other peak sequences using HOMER, MEME-ChIP (STREME, CentriMo,...
bio-chipseq-qc bioskills Assesses ChIP-seq quality across antibody specificity, fragmentation, enrichment, replicate concordance, and library complexity. Computes FRiP, NSC...
bio-chipseq-super-enhancers bioskills Identifies super-enhancers from H3K27ac, MED1, or BRD4 ChIP-seq using ROSE, ROSE2, LILY, HOMER -style super, and ENCODE dELS cross-referencing. Han...
bio-clip-seq-clip-motif-analysis bioskills Discover RBP binding motifs from CLIP-seq peaks or single-nucleotide crosslink sites using HOMER, MEME/STREME, kpLogo, mCross (CL-position-register...
bio-clip-seq-clip-qc bioskills Comprehensive quality control for CLIP-seq libraries (eCLIP, iCLIP, iCLIP2, PAR-CLIP) covering library complexity (preseq), FRiP, IDR replicate rep...
bio-copy-number-recurrent-cnv bioskills Identify recurrent and driver copy number alterations across a tumor cohort with GISTIC2 (G-score, Ziggurat deconstruction, focal vs broad/arm-leve...
bio-hi-c-analysis-compartment-analysis bioskills Detect A/B compartments from Hi-C data using cooltools and eigenvector decomposition. Identify active (A) and inactive (B) chromatin compartments f...
bio-hi-c-analysis-loop-calling bioskills Detect chromatin loops and point interactions from Hi-C data using cooltools, chromosight, and HiCCUPS-like methods. Identify CTCF-mediated loops a...
bio-long-read-sequencing-nanopore-methylation bioskills Calls DNA methylation from Oxford Nanopore sequencing data using signal-level analysis. Use when detecting 5mC or 6mA modifications directly from n...
bio-methylation-based-detection bioskills Analyzes cfDNA methylation patterns for cancer detection using cfMeDIP-seq or bisulfite sequencing with MethylDackel. Identifies cancer-specific me...
pptx openclaw Presentation creation, editing, and analysis. When Claude needs to work with presentations (.pptx files) for: (1) Creating new presentations, (2) M...
methylation-clock clawbio Compute epigenetic age from DNA methylation arrays using PyAging clocks from GEO accessions or local files.
methylation-cycle clawbio Methylation cycle analysis skill for ClawBio. Produces enzymatic activity
atac-seq bioclaw ATAC-seq processing with assay QC, MACS3 peak calling, consensus peak matrices, differential accessibility, and motif or footprint follow-up.
chip-seq bioclaw ChIP-seq peak calling and downstream interpretation with MACS3, signal track export, annotation, motif analysis, and differential binding review.
open-notebook kdense Self-hosted, open-source alternative to Google NotebookLM for AI-powered research and document analysis. Use when organizing research materials int...

Pathway Analysis

15 skills — KEGG, Reactome, GO, GSEA.

Skill Source Description
bio-pathway-enrichment-visualization bioskills Visualize enrichment results using enrichplot package functions. Use when creating publication-quality figures from clusterProfiler results. Covers...
bio-pathway-kegg-pathways bioskills KEGG pathway and module enrichment analysis using clusterProfiler enrichKEGG and enrichMKEGG. Use when identifying metabolic and signaling pathways...
bio-pathway-reactome bioskills Reactome pathway enrichment using ReactomePA package. Use when analyzing gene lists against Reactome's curated peer-reviewed pathway database. Perf...
bio-pathway-wikipathways bioskills WikiPathways enrichment using clusterProfiler and rWikiPathways. Use when analyzing gene lists against community-curated open-source pathways. Perf...
gsea-enrichment-analysis openclaw Gene set enrichment analysis with correct geneset format handling. Critical guidance for loading pathway databases and running enrichment in OmicVe...
ontology-explorer openclaw Parse, navigate, and query materials science ontology structure (classes, properties, hierarchy). Use when exploring an ontology like CMSO, underst...
ontology-mapper openclaw Map materials science terms, crystal structures, and sample descriptions to ontology classes and properties. Supports any ontology registered in on...
ontology-validator openclaw Validate material sample annotations and data structures against ontology constraints. Use when checking if CMSO annotations are correct, verifying...
tooluniverse-gene-enrichment openclaw Perform comprehensive gene enrichment and pathway analysis using gseapy (ORA and GSEA), PANTHER, STRING, Reactome, and 40+ ToolUniverse tools. Supp...
query-kegg bioclaw Query KEGG for biological pathways and gene info. Use when user asks about metabolic pathways, signaling pathways, pathway genes, or KEGG IDs. Trig...
query-reactome bioclaw Query Reactome for biological pathways and reactions. Use when user asks about signaling cascades, biological processes, pathway diagrams, or react...
generate-image kdense Generate or edit images using AI models (FLUX, Nano Banana 2). Use for general-purpose image generation including photos, illustrations, artwork, v...
scientific-schematics kdense Create publication-quality scientific diagrams using Nano Banana 2 AI with smart iterative refinement. Uses Gemini 3.1 Pro Preview for quality revi...
conn-tool neuroclaw Use this skill whenever the user wants to perform advanced functional connectivity (ROI-to-ROI, seed-to-voxel, ICA) or effective connectivity (PPI,...
Functional Enrichment Analysis (GSEA + ORA) omicsclaw Perform functional enrichment analysis using clusterProfiler on differential expression results with GSEA and ORA.

Metagenomics

9 skills — 16S/ITS amplicon, Kraken2, MetaPhlAn, QIIME2.

Skill Source Description
bio-blast-searches bioskills Run remote BLAST searches against NCBI servers using Biopython Bio.Blast.NCBIWWW. Use when identifying unknown sequences, finding homologs, picking...
bio-crispr-screens-screen-qc bioskills Quality control for pooled CRISPR screens covering library representation, Gini index, log-skew, replicate Pearson and Spearman concordance, essent...
bio-microbiome-qiime2-workflow bioskills QIIME2 command-line workflow for 16S/ITS amplicon analysis. Alternative to DADA2/phyloseq R workflow with built-in provenance tracking. Use when pr...
bio-microbiome-taxonomy-assignment bioskills Taxonomic classification of ASVs using reference databases like SILVA, GTDB, or UNITE. Covers naive Bayes classifiers (DADA2, IDTAXA) and exact mat...
microbiome-cancer-agent openclaw AI-powered analysis of microbiome-cancer interactions including tumor microbiome profiling, immunotherapy response prediction, and microbiome-targe...
meg-skill neuroclaw Use this skill whenever the user wants to process MEG (magnetoencephalography) data including source localization, time-frequency analysis, connect...
wmh-segmentation neuroclaw Use this skill whenever the user wants to perform automated white matter hyperintensity (WMH) segmentation on structural MRI data using the MARS-WM...
bio-annotation omics Functional annotation and taxonomy inference from sequence homology.
tracking-taxonomy-updates omics Track and reconcile taxonomy updates across NCBI, GTDB, ICTV, and community eukaryote frameworks with versioned provenance.

Protein Design

7 skills — RFDiffusion, ProteinMPNN, Boltz, Chai, LigandMPNN.

Skill Source Description
bio-clip-seq-m6a-clip bioskills Map N6-methyladenosine (m6A) RNA modifications at single-nucleotide resolution using miCLIP (Linder 2015), miCLIP2 + m6Aboost machine learning (Kor...
bio-tcr-bcr-analysis-immcantation-analysis bioskills Analyze BCR repertoires for somatic hypermutation, clonal lineages, and B cell phylogenetics using the Immcantation framework. Use when studying B...
mage-antibody-generator openclaw Ab seq forge
ligandmpnn adaptyv Ligand-aware protein sequence design using LigandMPNN. Use this skill when: (1) Designing sequences around small molecules, (2) Enzyme active site...
rfdiffusion adaptyv Generate protein backbones using RFdiffusion, a diffusion-based generative model for de novo protein structure generation. Use this skill when: (1)...
solublempnn adaptyv Solubility-optimized protein sequence design using SolubleMPNN. Use this skill when: (1) Designing for E. coli expression, (2) Optimizing solubilit...
generate_scientific_method_section labclaw Automated SCI-standard Methods section generator from experiment execution records. Parses LabOS skill call chains, structured JSON logs (extract_e...

NVIDIA BioNeMo Skills

17 skills — Official NVIDIA BioNeMo NIM API skills for protein structure prediction, molecular generation, and genomics.

View all 17 skills
Skill Type Description
boltz2-nim NIM API Boltz-2 biomolecular structure prediction via NVIDIA NIM API.
diffdock-nim NIM API DiffDock molecular docking via NVIDIA NIM API.
evo2-nim NIM API Evo2 genomic foundation model inference via NVIDIA NIM API.
genmol-nim NIM API GenMol molecule generation via NVIDIA NIM API.
molmim-nim NIM API MolMIM controlled molecular generation via NVIDIA NIM API.
msa-search-nim NIM API MSA search for protein structure prediction via NVIDIA NIM API.
openfold2-nim NIM API OpenFold2 protein structure prediction via NVIDIA NIM API.
openfold3-nim NIM API OpenFold3 biomolecular complex structure prediction via NVIDIA NIM API.
proteinmpnn-nim NIM API ProteinMPNN inverse folding / sequence design via NVIDIA NIM API.
rfdiffusion-nim NIM API RFdiffusion protein backbone design via NVIDIA NIM API.
proteina-complexa Open Model NVIDIA Proteina protein complex structure prediction.
kermt Open Model NVIDIA KERMT kernel estimation for molecular simulation.
cuEquivariance Library GPU-accelerated equivariant neural network operations.
genomics-workflow-acceleration Library Parabricks-powered GPU genomics pipeline acceleration.
nvMolKit Library NVIDIA molecular toolkit for cheminformatics and property prediction.
parabricks Library NVIDIA Parabricks GPU-accelerated GATK4 variant calling.
generative-protein-binder-design Workflow Multi-step binder design: RFdiffusion → ProteinMPNN → OpenFold3 via NIM APIs.

Source: NVIDIA-BioNeMo/bionemo-agent-toolkit · License: Apache-2.0 (code) / CC-BY-4.0 (skills)


Claude Science Skills

29 skills — Reverse-engineered Claude Science built-in skills covering biomolecular modeling, genomics, single-cell analysis, literature synthesis, and scientific compute workflows.

View all 29 skills
Skill Type Description
alphafold2 Structure AlphaFold2 monomer/multimer structure prediction via ColabFold runner.
boltz Structure Boltz-2 structure prediction for protein, nucleic-acid, and small-molecule complexes.
chai1 Structure Chai-1 foundation model structure prediction for biomolecular complexes.
esmfold2 Structure ESMFold2/ESMFold2-Fast all-atom co-folding with optional MSA.
openfold3 Structure OpenFold3 open-weights PyTorch reproduction of AlphaFold3.
fair-esm2 Embeddings Meta AI ESM-2 per-residue and per-sequence protein embeddings.
diffdock Docking DiffDock-L blind diffusion-based small-molecule pose prediction.
ligandmpnn Design LigandMPNN inverse folding with ligand, nucleic-acid, and metal context.
proteinmpnn Design ProteinMPNN inverse folding from PDB backbone to amino-acid sequences.
solublempnn Design SolubleMPNN solubility-biased inverse folding for expression-friendly designs.
evo2 Genomics Evo 2 long-context genomic foundation model for scoring, embedding, and generation.
borzoi Genomics Borzoi genome-wide functional track prediction (RNA-seq, CAGE, DNase, ChIP) from DNA.
scgpt Single-Cell scGPT single-cell expression embedding and annotation with a foundation model.
scvi-tools Single-Cell scVI/scANVI probabilistic single-cell RNA-seq: batch correction, annotation, integration.
literature-review Analysis Scientific literature search, verification, and synthesis from DOI or query.
indication-dossier Analysis Therapeutic indication dossier: epidemiology, disease biology, regulatory, trials.
paper-narrative Analysis Judge and reshape the story a paper's figures tell; narrative coherence analysis.
pdf-explore Analysis Deep PDF reading with annotation, cross-referencing, and structured extraction.
figure-composer Visualization Compose publication-grade multi-panel figures from data references and claims.
figure-style Visualization Publication figure correctness and legibility rules; applies to any plot output.
compute-env-setup Compute Set up and configure remote compute environments for Claude Science jobs.
remote-compute-modal Compute Run GPU jobs on the user's Modal account via BYOC provider.
remote-compute-ssh Compute Submit→wait→harvest workflow for SSH/SLURM HPC hosts.
managed-model-endpoints Compute Register and manage local model server containers as named endpoints.
using-model-endpoint Compute Call registered model endpoints over their native HTTP API from inference kernels.
customize Meta Create and configure custom agent profiles; author new skills via the repl tool.
skill-creator Meta Create, modify, benchmark, and improve skills with eval pipeline and scoring.
self-awareness Meta Claude Science session database schema and SDK introspection surface.
product-self-knowledge Meta Authoritative Claude Science factual self-knowledge; load before answering product questions.

Source: JimLiu/science-skills · License: Apache-2.0 · Reverse-engineered from Claude Science · Synced: fb309c3 (2026-07-01)


Sources

This collection aggregates and deduplicates skills from the following open-source repositories:

Repository Skills Focus
GPTomics/bioSkills 536 Systematic bioinformatics suite from QC to multi-omics.
FreedomIntelligence/OpenClaw-Medical-Skills 359 Medical AI library aggregating 12 specialized sub-repositories.
jaechang-hits/SciAgent-Skills 154 Scientific agent skills for statistics, databases, and clinical decisions.
K-Dense-AI/scientific-agent-skills 102 General scientific computing and HPC workflow skills.
CUHK-AIM-Group/NeuroClaw 86 Neuroimaging skills: sMRI, fMRI, dMRI, EEG with BIDS, FreeSurfer, FSL, fMRIPrep. CUHK AIM Group.
ClawBio/ClawBio 63 Bioinformatics workflow orchestration for GWAS and single-cell.
wu-yc/LabClaw 59 Lab automation and biomedical research skills. Stanford-Princeton AI Co-Scientists.
QSong-github/DrugClaw 57 Drug intelligence skills: DTI, ADR, DDI, pharmacogenomics, repurposing. LangGraph-powered.
ChrisLou-bioinfo/nobel-medicine-minds 55 Cognitive frameworks of 52 Nobel Medicine laureates (2004–2025) as runnable SKILL.md files.
zongtingwei/Bioclaw_Skills_Hub 46 Ten-category biological skills hub.
Runchuan-BU/BioClaw 37 Core bioinformatics tools and database query skills.
fmschulz/omics-skills 29 Single-cell and spatial omics specialized skills.
TianGzlab/OmicsClaw 28 6-omics domain skills: spatial, scRNA-seq, bulk RNA-seq, genomics, proteomics, metabolomics.
adaptyvbio/protein-design-skills 21 Full protein design toolkit: RFDiffusion, ProteinMPNN, Boltz, Chai.
aristoteleo/PantheonOS 18 Single-cell and spatial transcriptomics skills. Dynamo/Spateo team.
EvoScientist/EvoSkills 13 Research-lifecycle skills: ideation, paper planning, experiment execution, writing, and review.
xjtulyc/MedgeClaw 7 Biomedical research skills with real-time dashboard, RStudio, and JupyterLab integration.
zamushwani2/biomedical-ai-skills 4 Cancer multi-omics analysis skills in R.
ArcInstitute/SRAgent 1 Intelligent SRA and GEO dataset retrieval.
NVIDIA-BioNeMo/bionemo-agent-toolkit 17 Official NVIDIA BioNeMo NIM skills: Boltz-2, DiffDock, OpenFold2/3, RFdiffusion, ProteinMPNN, GenMol, Evo2, MolMIM, Parabricks.
JimLiu/science-skills 29 Reverse-engineered Claude Science built-in skills: structure prediction, design, genomics, single-cell, literature, and compute.
BioTender-max/awesome-bio-agent-skills 1 Self-referential hub skill that indexes this collection (browse & install entry point).

Skill Format

Each skill is a self-contained folder with a SKILL.md file defining domain knowledge, tool usage, and expected outputs. Compatible with any Claude-based agent framework supporting the SKILL.md convention.

skills/
└── <source>/
    └── <skill-name>/
        ├── SKILL.md          # Skill definition (required)
        └── ...               # Supporting files

Quick install:

git clone https://github.com/BioTender-max/awesome-bio-agent-skills.git
cp -r awesome-bio-agent-skills/skills/* /path/to/your/agent/skills/

A machine-readable index of all 1,693 skills is available in bioskill_index_v3.csv.


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